Research / 2022 / Article / Fig 1

Research Article

Comprehensive Humoral and Cellular Immune Responses to SARS-CoV-2 Variants in Diverse Chinese Population

Figure 1

Neutralizing antibody titers against SARS-CoV-2 wild type (WT) and variants of concern (VOCs). (a) The 50% neutralization titers (NAT50) were determined via VSV pseudovirus neutralization assay against WT (black dots), Alpha (yellow dots), Beta (purple dots), Delta (green dots), and Omicron (red dots) variants in all samples. (b) Comparison between vaccination sera and convalescent sera. (c) Subgroup analysis of age and vaccination status in Delta convalescents. (d) Subgroup analysis of SARS-CoV-1 infection history in healthy donors. (e) Subgroup analysis of vaccination status in healthy donors. Data are presented as scatter dot plots with error bars indicating the geometric mean titers (GMT) with a 95% confidence interval (CI). The GMT values are shown at the bottom of the dots. Fold-change of GMT compared to WT by VOCs is shown at the top of each group. Pie charts show the proportion of vaccinees within each group that had detectable neutralization against the indicated SARS-CoV-2 variants. All neutralization and ELISA assays were conducted in biological duplicates.