Space: Science & Technology / 2021 / Article / Tab 1

Research Article

Deep Membrane Proteome Profiling of Rat Hippocampus in Simulated Complex Space Environment by SWATH

Table 1

Differentially expressed proteins of endocytosis, glutamatergic synapse, and synaptic vesicle cycle.

Pathway nameDatabase accessionGene nameProtein nameFold change (SCSE/control)

EndocytosisB1WBS4Vps26bSimilar to vacuolar protein sorting 26 homolog (VPS26 protein homolog), isoform CRA_a5.16
D3ZL11RbsnRabenosyn, RAB effector2.66
G3V8J5PsdPH and SEC7 domain-containing protein 10.29
P18484Ap2a2AP-2 complex subunit alpha-23.26
F1LMX1Bin1Myc box-dependent-interacting protein 12.05
F1LUA1Eea1Early endosome antigen 10.25
E9PSY8Eps15Epidermal growth factor receptor pathway substrate 152.26
P26819Grk3Beta-adrenergic receptor kinase 27.09
P62332Arf6ADP-ribosylation factor 62.38
P08081CltaClathrin light chain A0.35
B2RZ72Arpc4Actin-related protein 2/3 complex subunit 43.86
D3ZXP7Arpc1aActin-related protein 2/3 complex subunit 1A2.67
P26817Grk2Beta-adrenergic receptor kinase 14.27
Q66HM2Ap2a2AP-2 complex subunit alpha3.24
F1LQP0Cyth3Cytohesin-32.91
Q99PD4Arpc1aActin-related protein 2/3 complex subunit 1A3.07
B5DEY8Snx6Sorting nexin2.33
A0A0A0MY49Dnm2Dynamin GTPase0.45
G3V8A5Vps35Vacuolar protein sorting-associated protein 352.53
B2RYP4Snx2Sorting nexin-22.18
B2RZ78Vps29Vacuolar protein sorting-associated protein 295.12
D3ZD48Rab11fip2RAB11 family interacting protein 2 (class I) (predicted), isoform CRA_a2.27
B1WBX6Smap2Small ArfGAP24.65
F1M8B7Chmp2bCharged multivesicular body protein 2B0.48
P29067Arrb2Beta-arrestin-27.41
G3V8M6Folr1Folate receptor 1 (adult), isoform CRA_b0.42
O08839Bin1Myc box-dependent-interacting protein 12.91
Q6AY86Vps26aVacuolar protein sorting-associated protein 26A8.65
B2RZB5Chmp2aCharged multivesicular body protein 2A2.65
B1H248Vps36Vacuolar protein-sorting-associated protein 363.82
Q8R491Ehd3EH domain-containing protein 33.10
Q99N27Snx1Sorting nexin-12.74
G3V9U1Agap1ArfGAP with GTPase domain, ankyrin repeat and PH domain 13.15
D3ZSI8Pip5k1aPhosphatidylinositol 4-phosphate 5-kinase type-1 alpha2.64
Q8R3Z7Ehd4EH-domain-containing 46.05
F1LMA4Grk2G protein-coupled receptor kinase4.98
Q4KLL7Vps4bVesicle-fusing ATPase5.29
M0RC57Smap1Small ArfGAP 13.33
B2GV73Arpc3Actin-related protein 2/3 complex subunit 35.92
B2GUV0Cyth1Cyth1 protein3.27
F1LSU6Cyth2Cytohesin-20.07
P0C0A1Vps25Vacuolar protein-sorting-associated protein 252.57
B2GUZ5Capza1F-actin-capping protein subunit alpha-13.49
D3ZKX1Washc3Coiled-coil domain-containing protein 532.81
D3ZJR1Eps15l1Epidermal growth factor receptor pathway substrate 15-like 12.66
Q9Z1Z3Epn2Epsin-23.10
P21575Dnm1Dynamin-13.99
B5DF55StamRCG557062.26

Glutamatergic synapseP19492Gria3Glutamate receptor 32.73
P10824Gnai1Guanine nucleotide-binding protein G(i) subunit alpha-10.32
Q63273Grik5Glutamate receptor ionotropic, kainate 50.30
D4A3N4Adcy1Adenylate cyclase type 12.31
G3V846Slc1a3Amino acid transporter4.14
P43425Gng7Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-74.63
P63100Ppp3r1Calcineurin subunit B type 13.14
P26819Grk3Beta-adrenergic receptor kinase 27.09
D4AE68GnaqGuanine nucleotide binding protein, alpha q polypeptide, isoform CRA_a2.74
G3V6R0Slc1a2Amino acid transporter0.17
M0RBJ0Gng2Guanine nucleotide-binding protein subunit gamma2.13
P26817Grk2Beta-adrenergic receptor kinase 14.27
Q9Z2X5Homer3Homer protein homolog 30.35
F1LS42PrkcbProtein kinase C0.44
Q9JHZ9Slc38a3Sodium-coupled neutral amino acid transporter 32.44
Q3KRE3Gng10Guanine nucleotide-binding protein subunit gamma3.24
M0R809Gng4Guanine nucleotide-binding protein subunit gamma3.24

Synaptic vesicle cycleP08081CltaClathrin light chain A0.35
P63041Cplx1Complexin-139.73
P62815Atp6v1b2V-type proton ATPase subunit B, brain isoform3.13
Q5FVI6Atp6v1c1V-type proton ATPase subunit C 12.66
P18484Ap2a2AP-2 complex subunit alpha3.26
P63081Atp6v0cV-type proton ATPase 16 kDa proteolipid subunit2.03
A0A0A0MY49Dnm2Dynamin GTPase0.45
P32851Stx1aSyntaxin-1A0.37
Q8R2H0Atp6v1g2V-type proton ATPase subunit G3.25
B2GUV5Atp6v1g1V-type proton ATPase subunit G2.07
P21575Dnm1Dynamin-13.99