Space: Science & Technology / 2021 / Article / Tab 2

Research Article

Investigation on P-Glycoprotein Function and Its Interacting Proteins under Simulated Microgravity

Table 2

Differentially expressed proteins interacted with P-gp under different SMG durations in rat brain.

No.Protein IDProtein nameFold change
7 d21 d

1P63312Thymosin beta-10 (Tmsb10)35.474.1
2P16086Spectrin alpha chain, nonerythrocytic 1 (Sptan1)6.270.787
3P0676178 kDa glucose-regulated protein (Hspa5)2.620.00
4P06685Sodium/potassium-transporting ATPase subunit alpha-1 (Atp1a1)2.120.340
5P07340Sodium/potassium-transporting ATPase subunit beta-1 (Atp1b1)2.000.00
6Q9QUL6Vesicle-fusing ATPase (Nsf)0.4870.205
7O08815STE20-like serine/threonine-protein kinase (Slk)0.4830.00
8Q5XIF6Tubulin alpha-4A chain (Tuba4a)0.4280.035
9Q6AXU4E3 ubiquitin-protein ligase RNF181 (Rnf181)0.3580.00
10P09606Glutamine synthetase (Glul)0.3220.00
11P61765Syntaxin-binding protein 1 (Stxbp1)0.2480.00
12P60203Myelin proteolipid protein (Plp1)0.1220.00
13P20760Ig gamma-2A chain C region (igg-2a)0.0160.001
14P04797Glyceraldehyde-3-phosphate dehydrogenase (GAPDH)0.000.00
15P10719ATP synthase subunit beta, mitochondrial (Atp5b)0.000.00
16P15999ATP synthase subunit alpha, mitochondrial (Atp5a1)0.000.00
17P48500Triosephosphate isomerase (Tpi1)0.000.00
18P51583Multifunctional protein ADE2 (Paics)0.000.00
19P62630Elongation factor 1-alpha 1 (Eef1a1)0.000.00
20P6303960 kDa heat shock protein, mitochondrial (Hspd1)0.000.00
21P69897Tubulin beta-5 chain (Tubb5)0.000.00
22Q62865cGMP-inhibited 3,5-cyclic phosphodiesterase A (Pde3a)0.000.00
23Q63488Sodium-dependent phosphate transporter 2 (Slc20a2)0.000.00
24Q6P9T8Tubulin beta-4B chain (Tubb4b)0.000.00
25Q99NA5Isocitrate dehydrogenase [NAD] subunit alpha (Idh3a)0.000.00
26Q9WVC0Septin-7 (7-Sep)0.000.00
27P37377Alpha-synuclein (Snca)993.0
28P06302Prothymosin alpha (Ptma)906.4
29P04764Alpha-enolase (Enol)174.9
30P48721Stress-70 protein, mitochondrial (Hspa9)150.9
31P34058Heat shock protein HSP 90-beta (Hsp90ab1)120.2
32P04642L-Lactate dehydrogenase A chain (Ldha)86.8
33P59215Guanine nucleotide-binding protein G(o)-alpha (Gnao1)66.0
34Q6IG01Keratin, type II cytoskeletal 1b (Krt77)15.9
35P10111Peptidyl-prolyl cis-trans isomerase A (Ppia)6.28
36P45592Cofilin-1 (Cfl1)4.51
37P63259Actin, cytoplasmic 2 (Actg1)0.429
38Q5M880PQ-loop repeat-containing protein 1 (Pqlc1)155.6
39P62628Dynein light chain roadblock-type 1 (Dynlrb1)24.8
40P07335Creatine kinase B-type (Ckb)18.9
41Q7M767Ubiquitin-conjugating enzyme E2 variant 2 (Ube2va)3.08
42P02564Myosin-7 (Myh-7)0.52
43P06686Sodium/potassium-transporting ATPase subunit alpha-2 (Atp1a2)0.00
44P11442Clathrin heavy chain 1 (Cltc)0.00
45P31596Excitatory amino acid transporter 2 (Slc1a2)0.00
46P62329Thymosin beta-4 (Tmsb4x)0.00
47P63018Heat shock cognate 71 kDa protein (Hspa8)0.00
48P85108Tubulin beta-2A chain (Tubb2a)0.00
49Q6P9V9Tubulin alpha-1B chain (Tuba1b)0.00