Alt text
Figure 5: Docking pose of 3 showing key interactions between the compound and PTP1B. (a) The protein is shown as light grey cartoon, while the catalytic loop, the YRD motif, and the WPD loop are colored green, yellow, and cyan, respectively; 3 is represented as a ball-and-stick model with carbon and oxygen colored magenta and red, respectively. (b) The protein is shown by molecular surface and 3 is represented as sticks. (c) Key interactions between 3 and PTP1B are analyzed by Ligplot+.