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Figure 2: Nanoprotein corona formation. (1) An initial corona forms from those proteins (blue) that arrive first to the surface (most abundant protein). (2) Initially adsorbed protein with low affinity (blue) is subsequently displaced by a different protein molecule with higher affinity (yellow) arriving later. (3) Another molecule (green) which had low affinity initially for the bare surface now adsorbs on the nanoparticle surface owing to favourable with the already adsorbed protein molecules (blue and yellow). (4) Another different protein molecule (red) cannot adsorb at all.